yes, and actually a lot of them:

• your web application needs to query the EOS network at each Web user request. You wouldn’t tolerate 100ms response time from a PB in this case
• you want to run some specific plugins (see my ZMQ plugin in this journal)
• you want an API URL which is highly available. This needs a cluster of load balancers and several nodeos servers in the back end. Public API at BP does not provide that, and they are down from time to time.